Protein C Test

[Lacie's Mom]

From Cornell University

Protein C Activity Assay

Protein C is a plasma anticoagulant factor required for maintenance of hemostatic balance. Protein C is synthesized in the liver and measurement of protein C activity aids in the diagnosis of thrombotic disorders and liver disease.

Protein C as a Biomarker of Liver Function Recent studies indicate that protein C deficiency is a marker of liver disease in dogs. Protein C deficiency develops in dogs with hepatic synthetic failure and in portosystemic shunting disorders.
The protein C activity assay is especially useful as a non-invasive measure of portal blood flow. Dogs with congenital portosystemic vascular anomalies (PSVA) typically have low protein C activity, with values < 70% of normal. Although clinical signs and chemistry profiles of dogs with PSVA and microvascular dysplasia are similar, the finding of low protein C activity supports a diagnosis of PSVA. Furthermore, protein C activities can be monitored after shunt ligation to assess restoration of portal blood flow.
Sample Requirements
Submit 0.5 to 1.0 mL of citrate plasma, shipped overnight on a cold pack
Test Turnaround and Costs
Same-day reporting: the test is run daily (M-F) with results faxed out as soon as the assay is complete
Protein C Activity assay fee
Test Principle
Test plasma is treated with a venom-derived activator, and the amount of functional protein C produced is measured in a chromogenic assay system. Results are reported as % protein C activity compared to a same-species standard. Protein C activity assays are routinely offered for dogs, cats, and horses. Please call for information on other species.
References
Toulza O, Center SA, Brooks MB, Warner K, Deal W. Protein C deficiency in dogs with liver disease. Proceedings of the 22 nd Annnual ACVIM Forum, Minneapolis, MN 2004; p. 866-867.
de Laforcade AM, Shaw SP, Freeman LM, Brooks MB, Rozanski EA, Rush JE. Coagulation parameters in dogs with naturally occurring sepsis. J Vet Intern Med 2003;17:674-679.
Mack CL, Superina RA, Whitington PF. Surgical restoration of portal flow corrects procoagulant and anticoagulant deficiencies associated with extrahepatic portal vein thrombosis. J Pediatr 2003;142:197-199.
Kottke-Marchant K, Comp P. Laboratory issues in diagnosing abnormalities of protein C, thrombomodulin, and endothelial cell protein C receptor. Arch Pathol Lab Med. 2002; 126:1337-48

[SammieMom]

Thank you Lynn-are these sticky threads?

[Ladysmom]

Originally Posted by SammieMom

Thank you Lynn-are these sticky threads?

Kandis, I asked Lynn to make stickies for the BAT procedure and Protein C test since I feel like I am posting the link everyday lately!

[SammieMom]

Ok, thanks. Great idea. I think it's figuring out what the results mean that confuses so many. On ALL the liver tests. I know once I understood that it was easy.